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4.6 Fertility, pregnancy and lactation Pregnancy There is inadequate evidence of the protection of codeine in human pregnancy, but there is epidemiological evidence for the safety of paracetamol. The two substances are made use of for a few years without having obvious ill consequences and animal studies have not revealed any hazard.You should not

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Caution is encouraged if paracetamol is administered concomitantly with flucloxacillin as a result of amplified possibility of substantial anion gap metabolic acidosis (HAGMA), specially in people with significant renal impairment, sepsis, malnutrition together with other sources of glutathione deficiency (e.Analytical cookies are used to know how

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A examine in rats and rabbits noted no teratogenic effect of codeine administered through the duration of organogenesis in doses ranging from five to 120 mg/kg. In the rat, doses on the a hundred and twenty mg/kg degree, inside the harmful assortment to the adult animal, were being linked to a rise in embryo resorption at the time of implantation.T

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